Brewery Profile
Two22 Brew
In Centennial’s craft beer landscape, this taproom stands out less for a specialized theme than for the role it assigns to each pour. Visitors walking in find a brewery built around neighborhood drafts and a giving model that is part of its identity, not a side note. The name refers to the 2:22 AM inspiration that led to its founding, and the business connects that origin story to a family legacy of giving back. Its defining public fact is straightforward: 22% of profits are dedicated to local Colorado non-profits. For someone exploring beer in the south Denver area, that makes the stop as much about community context as about what is on the draft board that day.
Travelers in Colorado often seek out small taprooms where the beer list reflects the neighborhood and where a visit feels different from buying a familiar label elsewhere. A stop here fits that pattern because the experience is centered on the taproom and its local ties. The available styles may change, and no specific year-round lineup should be assumed without checking directly, but the short description points to neighborhood-focused drafts rather than a single flagship identity. For visitors who like to pair a brewery stop with a sense of how a place participates in its community, Two22 Brew offers a clear angle: beer service tied to ongoing support for Colorado non-profits through its profit-sharing commitment.
Practical planning should start with the taproom, which is the place to confirm the day’s pours, hours, any current nonprofit focus, and details such as food options, seating, events, or family- and pet-related policies. Those amenities are not established here, so it is best not to assume them before going. The brewery is in Centennial, Colorado, making it a candidate for visitors staying or traveling on the south side of the metro area who want a local beer stop without needing a long detour. If the giving model is part of why you are visiting, ask at the bar how the current donations are being directed and which Colorado organizations are involved.
Two22 Brew in Centennial, Colorado, is more than just a taproom; it’s a mission-driven community hub where every pint supports a cause. Named for the 2:22 AM inspiration that led to its founding, this brewery dedicates a remarkable 22% of its profits to local Colorado non-profits, honoring a family legacy of giving back. Stop in for their neighborhood-focused drafts and experience craft beer that truly makes a difference.
Website available
4550 S Reservoir Rd, Centennial, Colorado, 80015-2878
Phone: 720-328-9038
Website: http://www.two22brew.com
Hours: Monday - Thursday Noon - 9PM Friday & Saturday Noon - 10PM Sunday Noon - 8PM
Upcoming Events
Upcoming public events currently attached to this brewery.
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Famous Amos Tacos
Oct 8, 2026
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Chicken Menace
Oct 9, 2026
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Colorado Coney Company
Oct 9, 2026
Food truck event serving Colorado Coney Company all day.
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Rustic Nomads
Oct 10, 2026
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Colorado Coney Company
Oct 11, 2026
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Poker Night
Oct 11, 2026
Poker Night event with cards, fun, and beer at Two22 Brew. Join the games and enjoy the atmosphere.
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Trivia Night
Oct 12, 2026
Weekly Trivia Night at Two22 Brew. Join for fun trivia, prizes, and great beer.
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Cruz In & Eat
Oct 13, 2026
Frequently Asked Questions
- Where is Two22 Brew located?
- Two22 Brew is located at 4550 S Reservoir Rd, Centennial, Colorado, 80015-2878. Use the map and directions on this page to plan your visit.
- What are Two22 Brew's hours?
- Current hours are: Monday - Thursday Noon - 9PM Friday & Saturday Noon - 10PM Sunday Noon - 8PM. Hours can change on holidays and during private events — call ahead if your visit is time-sensitive.
- How can I learn more about Two22 Brew?
- Visit http://www.two22brew.com for the brewery's own information about beers, events, and operations. Beer.Social aggregates public data and visitor-facing details to help with planning a stop.